Sponsor
BMBF Federal Ministry of Education and Research (FKZ 02WRS1282E)
Project executing organization: Karlsruhe Institute of Technology (KIT)
Realisation
German Federal Environment Agency, Department "Toxicology of drinking and swimming pool water", Bad Elster, Dr. Tamara Grummt (Project management)
RheinEnergie AG, Helmholtz-Centre for Environmental Research (UFZ), Hydrotox GmbH, German Institute of Human Nutrition (DIfE), Institute of Aerospace Medicine, University Heidelberg, Institute for Zoology, Incos Bote GmbH, RWTH Aachen, Institute for Environmental Research
Project duration
November 2011 - March 2015
Summary
Tox-Box is funded as part of the BMBF-funded action "Risk assessment of new pollutants and pathogens in the water cycle (RiSKWa). Within the ToxBox project a harmonized testing strategy for an exposure and hazard-based risk management of anthropogenic trace substances is developed and described in a guidance document. In the context of the continuous improvement of analytical techniques, an increasing number of chemical compounds in drinking water or in raw water for drinking water abstraction is detected, for which sufficient scientific knowledge about the toxicological effects is lacking. The risk assessment is based on health-related indication values, following the HRIV concept. Although the HRIV concept denominates the relevant biological endpoints (genotoxicity, neurotoxicity, endocrine effects, germ cell damage) it does not mention any procedure for the experimental survey of the toxicological data. Hydrotox is implementing part of the work package "in-vitro genotoxicity tests with mammalian cell lines". For this, standardised mammalian test systems were adapted to the scope of work. The micronucleus test with the cell line V-79 (chinese hamster lung cells) is performed according to OECD 487 (2010), the Mouse-Lymphoma-Assay with the cell line L5178Y TK+/- according to OECD 476 (1997). Both in-vitro genotoxicity tests aim detecting possible mutagenic and carcinogenic agents. Further information Detailed information is available on the website of the ToxBox.
Project Contact person at Hydrotox GmbH
Dipl. Biol. Martina Knauer
knauer(at)hydrotox.de
Tel: +49-(0)761-45512-22